How I Diagnose Angioimmunoblastic T-Cell Lymphoma

Yi Xie, MD, PhD; Elaine S. Jaffe, MD


Am J Clin Pathol. 2021;156(1):1-14. 

In This Article


AITL is a neoplasm of TFH cells with a constellation of clinical symptoms and pathologic characteristics that can pose diagnostic challenges. An integrated approach, incorporating clinical, histologic, immunophenotypic, and molecular findings, is essential to reach an accurate diagnosis. The growing knowledge of the molecular underpinnings of TFH lymphoma has improved our understanding of its pathobiology and will continue to aid in the diagnosis, especially of problematic cases, leading to a more precise classification and, eventually, better therapeutic strategies for patients with PTCL-TFH.