Semen Impairment and Occurrence of SARS-CoV-2 Virus in Semen After Recovery From COVID-19

M. Gacci; M. Coppi; E. Baldi; A. Sebastianelli; C. Zaccaro; S. Morselli; A. Pecoraro; A. Manera; R. Nicoletti; A. Liaci; C. Bisegna; L. Gemma; S. Giancane; S. Pollini; A. Antonelli; F. Lagi; S. Marchiani; S. Dabizzi; S. Degl'Innocenti F. Annunziato; M. Maggi; L. Vignozzi; A. Bartoloni; G.M. Rossolini; S. Serni


Hum Reprod. 2021;36(6):1520-1529. 

In This Article


The SARS-CoV-2 genome can be detected in biological fluids such as saliva, urine, and semen in a small percentage of sexually active men who have recovered from COVID-19. Even if our evidence suggests that the risk of SARS-CoV-2 sexual transmission after recovery in stable partners seems negligible, caution should be taken when managing the semen of healed COVID-19 patients during assisted reproduction and cryopreservation.

Most importantly, one-quarter of men who recovered from COVID-19 demonstrated oligo-crypto-azoospermia and signs of male genital tract inflammation, strictly related to disease severity. Therefore, our study suggests that COVID-19 patients of reproductive age should undergo a careful follow up for reproductive function and semen parameters.