Neoadjuvant Chemoimmunotherapy in Resectable Stage IIIA/IIIB Non-Small Cell Lung Cancer

Yulong Chen; Bo Yan; Feng Xu; Zhenzhen Hui; Gang Zhao; Jie Liu; Huan Zhang; Ziqing Zeng; Ran Zhang; Mariano Provencio; Xiubao Ren; Jian You


Transl Lung Cancer Res. 2021;10(5):2193-2204. 

In This Article


Neoadjuvant PD-1 blockade plus chemotherapy was associated with few side effects, did not delay surgery, and induced a pCR in 51.43% of resected tumors. The results of the current study support the widespread use of NCIO for resectable stage IIIA and IIIB NSCLC patients. No significant correlation was found between pathological response and PD-L1 expression, but the intracavitary and extracavitary tumors type was predictive of the pathological response to NCIO. Studies with a longer follow-up will be necessary to investigate whether MPR and pCR are associated with improved OS and PFS.