Alternative Therapies for Dry Eye Disease

Rhiya Mittal; Sneh Patel; Anat Galor


Curr Opin Ophthalmol. 2021;32(4):348-361. 

In This Article


Many therapeutic options exist for the treatment of DED, targeting different contributors of the disease. Potential therapeutics may target lacrimal gland hypofunction, MGD, inflammatory processes, and/or nerve abnormalities. Given the heterogeneity and complexity of DED, adjuvant and alternative therapies should be considered in individuals who fail first-line therapies. Although several therapies have been outlined in this review, continued research is needed to identify more options, test current therapies more robustly with control groups comparisons, and identify which subtypes of DED would best benefit from particular treatments.