Cutaneous Leishmaniasis Caused by an Unknown Leishmania Strain, Arizona, USA

Marcos de Almeida; Yueli Zheng; Fernanda S. Nascimento; Henry Bishop; Vitaliano A. Cama; Dhwani Batra; Yvette Unoarumhi; Abaseen K. Afghan; Vivian Y. Shi; Philip E. LeBoit; Eugene W. Liu; Fariba M. Donovan

Disclosures

Emerging Infectious Diseases. 2021;27(6):1714-1717. 

In This Article

Abstract and Introduction

Abstract

We investigated an autochthonous case of cutaneous leishmaniasis caused by a genetically different Leishmania sp. in a patient in Arizona, USA. This parasite was classified into the subgenus Leishmania on the basis of multilocus DNA sequence and phylogenetic analyses of the rRNA locus and 11 reference genes.

Introduction

Human leishmaniasis is a vectorborne disease occurring mostly in Central and South America, the Europe/Africa Mediterranean area, the Middle East, and the Indian subcontinent. This disease is caused by parasites in the Leishmania subgenera Viannia and Leishmania, affects ≈2.5 million persons, and causes 60,000 deaths yearly worldwide.[1] The disease has 3 main clinical forms: cutaneous leishmaniasis (CL), the most prevalent form and caused by species in both Viannia and Leishmania subgenera; mucocutaneous leishmaniasis, caused by species in the subgenus Viannia; and visceral leishmaniasis, caused by L. (L.) donovani and L. (L.) infantum. These syndromes might lead to social stigma because of permanent scars, skin disfigurement, and partial/total destruction of oral/nasopharyngeal mucosa and can result in systemic symptoms including splenomegaly, wasting, and even death.[2]

Species-specific Leishmania identification is critical in clinical management and epidemiologic investigations.[2] Detection and identification of Leishmania parasites were traditionally done through microscopic and multilocus enzyme electrophoresis analysis. Currently, PCR-based methods and multilocus DNA sequence analyses (MLSA) combined with next-generation sequencing, have improved phylogenetic resolution and provided insights into parasite identification, classification, genetic polymorphism, virulence, and drug resistance.[3,4]

Leishmania parasites are emerging in previously nonendemic areas;[5] traditional and exotic Leishmania species/strains have been reported in focal areas of the Americas, Europe, Africa, Asia, and the Western Pacific.[6] In the United States, leishmaniasis is mostly nonreportable and historically considered a travel-associated disease. However, the activity of natural vectors of Leishmania and occurrence of autochthonous zoonotic cases of CL and visceral leishmaniasis caused by L. (L.) mexicana or L. (L.) infantum have been reported in several states, including Alabama, Arizona, Arkansas, Delaware, Georgia, Kentucky, Louisiana, Maryland, Mississippi, Ohio, Oklahoma, South Carolina, and Texas.[7–10] Those reports suggest the possibility of local transmission of leishmaniasis, especially in the southwestern US region. We report an autochthonous case of CL from Arizona, USA, caused by an unknown parasite in the subgenus Leishmania.

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