Recent Randomized Trials of Antithrombotic Therapy for Patients With COVID-19

JACC State-of-the-Art Review

Azita H. Talasaz, PHARMD; Parham Sadeghipour, MD; Hessam Kakavand, PHARMD; Maryam Aghakouchakzadeh, PHARMD; Elaheh Kordzadeh-Kermani, PHARMD; Benjamin W. Van Tassell, PHARMD; Azin Gheymati, PHARMD; Hamid Ariannejad, MD; Seyed Hossein Hosseini, PHARMD; Sepehr Jamalkhani; Michelle Sholzberg, MDCM, MSC; Manuel Monreal, MD, PHD; David Jimenez, MD, PHD; Gregory Piazza, MD, MS; Sahil A. Parikh, MD; Ajay J. Kirtane, MD, SM; John W. Eikelboom, MBBS; Jean M. Connors, MD; Beverley J. Hunt, MD; Stavros V. Konstantinides, MD, PHD; Mary Cushman, MD, MSC; Jeffrey I. Weitz, MD; Gregg W. Stone, MD; Harlan M. Krumholz, MD, SM; Gregory Y.H. Lip, MD; Samuel Z. Goldhaber, MD; Behnood Bikdeli, MD, MS


J Am Coll Cardiol. 2021;77(15):1903-1921. 

In This Article


We conducted a systematic literature search of trials in and the World Health Organization (WHO) International Clinical Trials Registry Platform, with the pre-defined key words of COVID-19 and search terms for antiplatelet agents, anticoagulants, anticoagulation, fibrinolytic agents, and antithrombotic agents. The identified studies were screened, and those that were designed as RCTs with at least 1 active arm of antithrombotic therapy (date of last search December 16, 2020) were included. Supplemental Table 1 summarizes study-level inclusion and exclusion criteria for this review.

For the included studies, PubMed and MedRxiv were searched for design papers, study protocols, or published results of those studies. The list was complemented by hand-searching and discussion within the author group.