Efficacy and Safety of Gout Flare Prophylaxis and Therapy Use in People With Chronic Kidney Disease

A Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN)-Initiated Literature Review

Huai Leng Pisaniello; Mark C. Fisher; Hamish Farquhar; Ana Beatriz Vargas-Santos; Catherine L. Hill; Lisa K. Stamp; Angelo L. Gaffo


Arthritis Res Ther. 2021;23(130) 

In This Article


In summary, this review has described the current literature on the efficacy and safety of gout flare prophylaxis and therapy use in people with gout and concomitant CKD. The dearth of high-quality data reporting in this high-risk comorbid population is concerning, especially in clinical trials. Currently, treating clinicians have no evidence-based approaches to manage flares or prophylaxis in patients with gout and advanced CKD. Current and future gout flare studies should include patients with CKD and inform study results stratified by renal function as well as using standardised gout flare definitions in the study design. With these key steps, results of future gout flare prophylaxis and treatment studies will guide better and systematic evidence-informed approach in managing gout flares and prophylaxis in patients with advanced CKD.