Long-Term Efficacy and Safety of Gonadotropin-Releasing Hormone Analog Treatment in Children With Idiopathic Central Precocious Puberty

A Systematic Review and Meta-Analysis

Xiaoping Luo; Yan Liang; Ling Hou; Wei Wu; Yanqin Ying; Feng Ye


Clin Endocrinol. 2021;94(5):786-796. 

In This Article


Compared with no treatment, the current evidence indicates that GnRHa treatment improve the FAH of girls with ICPP, thus allowing them to meet or exceed their TH. GnRHa treatment also reduce the BMI levels of participants compared with BMI of those treated with placebo. Furthermore, GnRHa did not appear to increase the risk of PCOS. However, evidence regarding other predefined key outcomes, such as infertility, malignancy and metabolic diseases, is very weak to indicate the benefits or side effects of GnRHa treatment.