Liver Stiffness by Magnetic Resonance Elastography Is Associated With Increased Risk of Cardiovascular Disease in Patients With Non-alcoholic Fatty Liver Disease

Jung Gil Park; Jinho Jung; Kritin K. Verma; Min Kyu Kang; Egbert Madamba; Scarlett Lopez; Aed Qas Yonan; Amy Liu; Ricki Bettencourt; Claude Sirlin; Rohit Loomba


Aliment Pharmacol Ther. 2021;53(9):1030-1037. 

In This Article

Future Implications

Even though some patients with NAFLD were classified as having a low CVD risk by the traditional risk-scoring models, significant fibrosis was an independent predictor for subclinical CVD. These results suggest that FRS is not enough to assess the risk of CVD in patients with NAFLD. Thus, in order to evaluate the risk of CVD in patients with NAFLD, liver stiffness should be considered. In addition, models for assessing the risk of CVD in patients with NAFLD, including traditional risk factors for CVD, need to be investigated in the near future.

In conclusion, liver stiffness by MRE is an independent factor for the risk of the presence of CAC in patients with NAFLD. Patients with MRE ≥ 2.97 kPa should be considered for cardiovascular risk assessment, regardless of their FRS.