Is Treating Patients With Stage 4 Pressure Ulcers With Vitamins A and C, Zinc, and Arginine Justified?

Kunaal Bafna, MS; Tian Chen, PhD; Richard Simman, MD, FACS, FACCWS


Wounds. 2021;33(3):77-80. 

In This Article


Overall, the treatment of pressure ulcers will continue to be increasingly relevant as the population ages and chronic disease becomes more prevalent. The findings of the current study suggest that albumin and prealbumin deficiency are variably correlative with vitamin deficiency; therefore, patients may need to undergo more adequate assessment of deficiency before vitamin supplementation is begun in the context of nutritional depletion. For example, in this analysis, arginine and zinc deficiencies are positively correlative with albumin deficiency, but vitamin C deficiency was less likely to be correlated with albumin deficiency. Therefore, why should vitamin C supplementation be initiated in chronic wound patients simply on the basis of presumed albumin deficiency? It is increasingly important to gather evidence elucidating the effectiveness of treatment mechanisms for patients suffering from chronic wounds. Additional research will hopefully uncover whether protocoled vitamin supplementation in patients with chronic pressure ulcers and wounds is, in fact, justified.