Kidney Stone Formers at Greater Risk of Developing Metabolic Syndrome

Sarfaroj Khan 


April 14, 2021


Why this matters

  • Findings warrant routine assessment for components of MetS when assessing kidney SFs, given the further risk of kidney stone disease and the long-term cardiovascular implications.

Study design

  • This comparative cohort study included 828 kidney SFs referred to a metabolic centre in Southern England and 2484 age- and sex-matched non-SF comparators (control group) with a median follow-up of 19 years.

  • MetS was defined as per the modified Association of American Clinical Endocrinologists criteria.

  • Funding: None disclosed.

Key results

  • Kidney SFs vs control individuals had a significantly increased risk of MetS (43.6% vs 24.8%; adjusted HR [aHR], 1.77; 95% CI, 1.55-2.03; P<.001).

  • This association remained robust after adjustment for the presence of previous components of MetS (aHR, 1.91; 95% CI, 1.66-2.19; P<.001).

  • This effect was consistent with sub-analyses of no previous components of MetS (aHR, 1.98; 95% CI, 1.69-2.31; P<.001) and 1 or 2 previous components of MetS (aHR, 1.54; 95% CI, 1.11-2.14; P=.011).

  • Sub-analyses of stone types demonstrated that patients with calcium oxalate stones (aHR, 1.82; 95% CI, 1.53-2.16; P<.001) and urate stones (aHR, 3.87; 95% CI, 2.23-6.72; P<.001) had an increased risk of MetS.

  • Other stone types were not linked with a significantly increased risk of MetS.


  • Risk of under-ascertainment of MetS at baseline.


Geraghty RM, Cook P, Roderick P, Somani B. Risk of Metabolic Syndrome in Kidney Stone Formers: A Comparative Cohort Study with a Median Follow-Up of 19 Years. J Clin Med. 2021;10(5):978. doi: 10.3390/jcm10050978. PMID: 33801183.  View full text 

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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