Novel Strategies for Healthy Brain Aging

Devin Wahl; Alyssa N. Cavalier; Thomas J. LaRocca


Exerc Sport Sci Rev. 2021;49(2):115-125. 

In This Article


Based on the available evidence, it seems likely that developing novel strategies to target central, exercise-relevant energy-sensing pathways is a particularly promising direction for future research aimed at promoting healthy brain aging. New strategies like those outlined above will need to be tested in preclinical models and then carefully controlled clinical studies for feasibility, safety, and efficacy — but given the importance of healthy brain aging and dementia prevention, we suspect that such endeavors will be well worth the effort.