High-Flow Nasal Oxygen in Patients With COVID-19-Associated Acute Respiratory Failure

Ricard Mellado-Artigas; Bruno L. Ferreyro; Federico Angriman; Maria Hernandez-Sanz; Egoitz Arruti; Antoni Torres; Jesus Villar; Laurent Brochard; Carlos Ferrando


Crit Care. 2021;25(58) 

In This Article


In this observational study of 122 matched adult critically-ill patients with COVID-19-associated acute respiratory failure receiving either HFNO or early intubation upon ICU admission, the use of HFNO was associated with increased VFDs and a reduction in the duration of ICU stay, with no differences in all-cause in-hospital mortality. However, caution is warranted before drawing definite conclusions since, in the whole population, those intubated early were sicker, and even the most thorough statistical adjustment cannot eliminate confounding entirely. Future studies should corroborate our findings, as a way of optimizing the ventilation strategy for patients with COVID-19 associated acute respiratory failure.