Smoking Status and Mortality Outcomes Following PCI

Sarfaroj Khan 


March 09, 2021


  • Smokers undergo percutaneous coronary intervention (PCI) at a much younger age and more commonly for acute coronary syndrome (ACS) vs never-smokers.

  • Current smoking is associated with increased 30-day mortality.

  • Ex-smokers and never-smokers have similar presentation age for PCI, and there is no short (30-day) or intermediate (30-day to 6-month) mortality difference between them following PCI.

Why this matters

  • Findings reinforce the public message of the harmful effects of smoking and benefits of smoking cessation.

Study design

  • This retrospective analysis compared short and intermediate mortality following PCI among never-smokers (n=4288), ex-smokers (n=4806) and current smokers (n=3562).

  • Funding: None.

Key results

  • The mean age (±standard deviation [SD]) was 57 (±11) years in current smokers vs 67 (±11) years in ex-smokers and 67 (±12) years in never-smokers (P<.001).

  • The proportion of patients undergoing PCI for ACS was highest in current smokers (84.1%) vs ex-smokers (57.0%) and never-smokers (62.9%) (P<.0001).

  • Compared with never-smokers, the adjusted ORs (95% CIs) for 30-day mortality were 1.60 (1.10-2.32) in current smokers and 0.98 (0.70-1.38) in ex-smokers.

  • Compared with never-smokers, the adjusted HRs (95% CIs) for mortality between 30 days and 6 months were 1.03 (0.65-1.65) in current smokers and 1.19 (0.84-1.67) in ex-smokers.


  • Retrospective design.

  • Lack of data on smoking intensity and duration of smoking cessation in ex-smokers.


Parasuraman S, Zaman AG, Egred M, Bagnall A, Broadhurst PA, Ahmed J, Edwards R, Das R, Garg D, Purcell I, Noman A. Smoking status and mortality outcomes following percutaneous coronary intervention. Eur J Prev Cardiol. 2020 Feb 4 [Epub ahead of print]. doi: 10.1177/2047487320902325. PMID: 33611373.  View abstract 

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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