Impact of COVID-19 in Solid Organ Transplant Recipients

Lara Danziger-Isakov; Emily A. Blumberg; Oriol Manuel; Martina Sester


American Journal of Transplantation. 2021;21(3):925-937. 

In This Article

Transplantation as Treatment for Severe COVID-19

Given concerns for irreversible organ damage especially to the lungs from COVID-19, there has been increasing interest in transplantation for COVID-19 induced end-stage lung disease. First cases of lung transplantation in patients with COVID-19 have been reported in China and in Austria. In China, five lung transplantations were reported in PCR negative patients; one patient died 1 day after surgery.[165,166] An Austrian team reported successful lung transplantation of a 44-year-old woman.[167] Her PCR was still positive but non-infectivity was confirmed by negative culture. Two additional cases who had developed end-stage pulmonary fibrosis have been transplanted in the United States.[168] Careful definition of clinical indications[169] and long-term results are needed to more safely delineate when to consider transplantation as a treatment option for end-stage lung disease.