Arthritis as an Initial Presentation of Malignancy

Two Case Reports

Benjamin Sachdev Manjit Singh; Sharifah Aishah Wan; Yaw Kiet Cheong; Seow Lin Chuah; Cheng Lay The; Ahmad Tirmizi Jobli


J Med Case Reports. 2021;15(94) 

In This Article


Paraneoplastic syndromes are a collection of signs and symptoms caused by organ or tissue damage occurring at locations distant from primary tumors.[1] These symptoms may develop before, concurrent with, or after the diagnosis of a malignancy.[2] Interestingly, malignancies have been associated with a wide variety of paraneoplastic rheumatic manifestations which may develop in joints, fascia, muscles, vessels or bones, often mimicking the presentation of primary rheumatic diseases such as spondyloarthropathy (SpA), rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or vasculitis.[2] We report two patients whose cases were initially diagnosed and treated as rheumatic diseases but were later found to be paraneoplastic arthritis related to malignancy.