WHO Experts Strongly Advise Against Hydroxychloroquine to Prevent COVID-19

Dawn O'Shea

March 04, 2021

Editor's note: Find the latest COVID-19 news and guidance in Medscape's Coronavirus Resource Center.

The World Health Organization (WHO) Guideline Development Group (GDG) is strongly advising against the use of hydroxychloroquine to prevent COVID-19. The group says the drug should no longer be a research priority.

The recommendations are based on evidence from six randomised controlled trials involving over 6,000 participants with and without known exposure to a person with COVID-19 infection.

The "high certainty" evidence showed that hydroxychloroquine had no meaningful effect on death and admission to hospital, while moderate certainty evidence showed that hydroxychloroquine had no meaningful effect on laboratory-confirmed COVID-19 infection, and it probably increases the risk of adverse effects.

Consequently, the GDG considers that this drug is no longer a research priority and that resources should be used to evaluate other, more promising drugs to prevent COVID-19.

The WHO says this guidance, published today (2 March 2021) in the British Medical Journal, is the first version of a living guideline for drugs to prevent COVID-19. New recommendations for other preventive drugs for COVID-19 will be added to this guideline as more evidence becomes available.

Follow the latest COVID-19 figures in your region and around the globe with our interactive COVID-19 map.

References

Lamontagne F, Agoritsas T, Siemieniuk R, Rochwerg B, Bartoszko J, Askie L, et al. Rapid Recommendations: A living WHO guideline on drugs to prevent COVID-19. BMJ 2021;372:n526. http://dx.doi.org/10.1136/bmj.n526

This article originally appeared on Univadis, part of the Medscape Professional Network.

Comments

3090D553-9492-4563-8681-AD288FA52ACE
Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as:

processing....