Aspirin vs Dual Antiplatelet Therapy in Patients Undergoing TAVI

Sarfaroj Khan 


February 24, 2021


  • This meta-analysis suggests that the use of aspirin reduces the risk of bleeding without an increase in ischaemic events following transcatheter aortic valve implantation (TAVI) procedures compared with dual antiplatelet therapy (DAPT).

Why this matters

  • Findings support the results of the recently published POPular-TAVI trial reporting the safety of using aspirin over DAPT.

  • Findings together with the results of POPular-TAVI trial will inform physicians in formulating local and national guidelines on antiplatelet therapy in patients undergoing TAVI.

Study design

  • Meta-analysis of 4 randomised clinical trials, including 1086 patients receiving antiplatelet therapy following TAVI.

  • Funding: None disclosed.

Key results

  • After a median follow-up of 6 months, the aspirin vs DAPT group had a significantly lower risk of major or life-threatening bleeding (rate ratio [RR], 0.49; 95% CI, 0.31-0.78).

  • Aspirin was not associated with an increased risk of:

    • death (RR, 1.01; 95% CI, 0.62-1.65);

    • cardiovascular death (RR, 1.15; 95% CI, 0.56-2.36);

    • ischaemic stroke (RR, 0.93; 95% CI, 0.51-1.70); and

    • myocardial infarction (MI; RR, 0.53; 95% CI, 0.18-1.57).

  • Rates of adverse events (combination of major or life-threatening bleeding and death, MI or stroke) were 15.9% in the aspirin group vs 22.6% in the DAPT group.


  • Limited number of studies.


Alkhalil M, Edwards R, Puri R, Kalra A, Zaman A, Das R. Aspirin Versus Dual Antiplatelet Therapy in Patients Undergoing Trans-Catheter Aortic Valve Implantation, Updated Meta-Analysis. Cardiovasc Drugs Ther. 2021 Feb 15 [Epub ahead of print]. doi: 10.1007/s10557-021-07146-6. PMID: 33587229.   View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: