Takeaway
This meta-analysis suggests that the use of aspirin reduces the risk of bleeding without an increase in ischaemic events following transcatheter aortic valve implantation (TAVI) procedures compared with dual antiplatelet therapy (DAPT).
Why this matters
Findings support the results of the recently published POPular-TAVI trial reporting the safety of using aspirin over DAPT.
Findings together with the results of POPular-TAVI trial will inform physicians in formulating local and national guidelines on antiplatelet therapy in patients undergoing TAVI.
Study design
Meta-analysis of 4 randomised clinical trials, including 1086 patients receiving antiplatelet therapy following TAVI.
Funding: None disclosed.
Key results
After a median follow-up of 6 months, the aspirin vs DAPT group had a significantly lower risk of major or life-threatening bleeding (rate ratio [RR], 0.49; 95% CI, 0.31-0.78).
Aspirin was not associated with an increased risk of:
death (RR, 1.01; 95% CI, 0.62-1.65);
cardiovascular death (RR, 1.15; 95% CI, 0.56-2.36);
ischaemic stroke (RR, 0.93; 95% CI, 0.51-1.70); and
myocardial infarction (MI; RR, 0.53; 95% CI, 0.18-1.57).
Rates of adverse events (combination of major or life-threatening bleeding and death, MI or stroke) were 15.9% in the aspirin group vs 22.6% in the DAPT group.
Limitations
Limited number of studies.
This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.
© 2021 WebMD, LLC
Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Sarfaroj Khan. Aspirin vs Dual Antiplatelet Therapy in Patients Undergoing TAVI - Medscape - Feb 24, 2021.
Comments