Knowledge Translation Tools to Guide Care of Non-Intubated Patients With Acute Respiratory Illness During the COVID-19 Pandemic

David Leasa; Paul Cameron; Kimia Honarmand; Tina Mele; Karen J. Bosma


Crit Care. 2021;25(22) 

In This Article

Methods Used to Develop the Knowledge Translation Tools

The multidisciplinary Ventilation Strategy for COVID-19 Working Group held its first virtual meeting 25 March 2020. Our aim was to minimize the risk of viral transmission with NRS strategies among various subgroups of patients and provide clear guidance to our front-line HCP on early management of patients with suspected or confirmed COVID-19. Our methodology included virtual discussion groups using Microsoft Teams® and Zoom® meeting software, evaluation of emerging published scientific literature, grey literature, Society (e.g., ESICM) webinars and newsletters, national/international health organization reports, as well as drawing upon email groups/personal communication with HCPs around the world to learn from their experience. Key articles were retrieved using OMNI Academic Search Tool ( which includes PubMed, Google Scholar, Scopus, MEDLINE and others, using search terms COVID-19; SARS-CoV-2; hypoxemic respiratory failure; and treatment. Time was critical. By 6 April 2020, we had our first documents approved by hospital leadership and available for use in our centre, which served our staff through the first wave of COVID-19. Updates were disseminated in April, July and September, 2020, as new information became available. Guidance issued around best practice in COVID-19 is based on low levels of evidence (case series, small observational studies, expert opinion, or extrapolated data).[6] We share our approach with advisement that further research is required to answer several key questions, (see Recommendations for Clinical Practice and Future Research, Additional file 1) and encourage enrolment in randomized controlled trials where possible.