Coronavirus Disease 2019
While some initial case reports suggested that a prothrombotic state occurs in some patients with COVID-19 that may manifest as LVO, population-based data have yet to report an increased incidence of ischemic stroke.[30,31] In fact, stroke admissions may have fallen overall.[32,33] Finally, we recommend several publications that have addressed acute stroke care process to maximize safety for patients and health care personnel.[34–37]
Acknowledgments
We would like to acknowledge input from many members of the stroke community who sent suggestions and comments by email.
Sources of Funding
None.
Nonstandard Abbreviation and Acronyms
ACT = Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke: QuICR & OPTIMISE Registry Based Pragmatic Randomized Controlled Trial
ATACH-2 = Antihypertensive Treatment of Acute Cerebral Hemorrhage 2
BASICS = Basilar Artery International Cooperation Study
BEST = Acute Basilar Artery Occlusion: Endovascular Interventions Versus Standard Medical Treatment
COVID-19 = coronavirus disease 2019
DIRECT-MT = Direct Intraarterial Thrombectomy to Revascularize AIS Patients With Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals: a Multicentre Clinical Trial
DIRECT-SAFE = Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis With Endovascular Clot Retrieval Within 4.5 Hours of Stroke Onset
ESCAPE = Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on minimizing CT to Recanalization Times
ESCAPE-NA1 = Extension of Stroke Care by Added neuroProtection to Endovascular treatment
ESCAPE-NEXT = Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis
EVT = endovascular thrombectomy/treatment
EXTEND-IA TNK = Extending the Time for Thrombolysis in Emergency Neurological Deficits—IntraArterial Using Intravenous Tenecteplase
INTERRSeCT = Identifying New Approaches to Optimize Thrombus Characterization for Predicting Early Recanalization and Reperfusion With IV Alteplase and Other Treatments Using Serial CT Angiography
LVO = large vessel occlusion
MR-CLEAN NoIV = Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands No IV Thrombolysis
NORTEST-2 = Norwegian Tenecteplase Stroke Trial 2: A Randomised Trial of Tenecteplase Versus Alteplase in Acute Ischemic Stroke
RESILIENT = Randomization of Endovascular Treatment With Stent-retriever and/or Thromboaspiration Versus Best Medical Therapy in Acute Ischemic Stroke Due to Large Vessel Occlusion Trial
SKIP = Randomised Study of Endovascular Therapy With Versus Without Intravenous Tissue Plasminogen Activator in Acute Stroke With ICA and M1 Occlusion
STOP-AUST = Spot Sign and Tranexamic Acid On Preventing ICH Growth—Australasia Trial
SWIFT-DIRECT = Solitaire™ With the Intention for Thrombectomy Plus Intravenous t-PA Versus DIRECT Solitaire™ Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke
TASTE: Tenecteplase Versus Alteplase for Stroke Thrombolysis Evaluation
TEMPO-2: Multicentre, Prospective Randomized Open Label, Blinded-End Point (PROBE) Controlled Trial of Thrombolysis With Low Dose Tenecteplase (TNK-tPA) Versus Standard of Care in Minor Ischemic Stroke With Proven Acute Symptomatic Occlusion
TOACT: Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis
TWIST: Tenecteplase in Wake-up Ischaemic Stroke Trial (TWIST). A Randomised-controlled Trial of Thrombolytic Treatment With Tenecteplase for Acute Ischaemic Stroke Upon Awakening
Stroke. 2021;52(2):729-734. © 2021 American Heart Association, Inc.
