Advances in Acute Stroke Treatment 2020

Joseph P. Broderick, MD; Michael D. Hill, MD, MSc, FRCPC


Stroke. 2021;52(2):729-734. 

Cortical Venous Sinus Thrombosis

Cortical venous sinus thrombosis is the least common form of stroke and randomized data on cortical venous sinus thrombosis management, both acute and chronic, are sparse. The TOACT study (Thrombolysis or Anticoagulation for Cerebral Venous Thrombosis; n=67), assessing endovascular treatment (mechanical with or without local thrombolytic drug infusion) versus best medical care was conducted in Europe and China.[29] There was no difference in outcomes at 1 year with two-thirds of the population in both groups achieving modified Rankin Scale score of 0 to 1 (relative risk ratio, 0.99 [95% CI, 0.71–1.38]). Given its low prevalence relative to other stroke types, continued global collaboration on cortical venous sinus thrombosis trials is needed.