SARS-CoV-2 in First Trimester Pregnancy

A Cohort Study

N. la Cour Freiesleben; P. Egerup; K.V.R. Hviid; E.R. Severinsen; A.M. Kolte; D. Westergaard; L. Fich Olsen; L. Prætorius; A. Zedeler; A.-M.H. Christiansen; J.R. Nielsen; D. Bang; S. Berntsen; J. Ollé-López; A. Ingham; J. Bello-Rodríguez; D.M. Storm; J. Ethelberg-Findsen; E.R. Hoffmann; C. Wilken-Jensen; F.S. Jørgensen; H. Westh; H.L. Jørgensen; H.S. Nielsen


Hum Reprod. 2021;36(1):40-47. 

In This Article


This study focused on possible signs of maternal SARS-CoV-2 infection in first trimester pregnancies. We found no significant different nuchal translucency thickness at the first trimester scan among pregnant women with previous SARS-CoV-2 infection in early pregnancy compared to women without previous SARS-CoV-2 infection. Furthermore, we found no significantly increased risk of pregnancy loss in women with SARS-CoV-2 infection in the first trimester. Serological studies investigating the impact of SARS-CoV-2 on later stages of pregnancy are needed to develop clinical guidelines and recommendations for any possible restrictions for pregnant women in relation to SARS-CoV-2.