Metabolic Effect of Breaking Up Prolonged Sitting With Stair Climbing Exercise Snacks

Hossein Rafiei; Kosar Omidian; Étienne Myette-Côté; Jonathan Peter Little

Disclosures

Med Sci Sports Exerc. 2021;53(1):150-158. 

In This Article

AUC

Insulin, glucose, and NEFA over time and total AUCs in participants with HW and OW are presented in Figures 2–4. Positive incremental AUC analyses resulted in the same general conclusions and are presented in Supplemental Figure 1 (Figure, Supplemental Digital Content 2, Incremental AUC analyses in young healthy weight men (left) or adults with overweight/obesity (right), http://links.lww.com/MSS/C39).

Figure 2.

Insulin over time and total AUC in the HW (top) or OW (bottom) group. Nine-hour insulin over time and total AUC in the HW (A, B) or OW (C, D) group. Participants were sedentary for 9 h with three identical meals (SED) or performed 15–30 s of stair climbing "snacks" every hour (SS), with the same meals provided at 0, 180, and 360 min. *P < 0.05; t-test was used to compare AUCs between the conditions within each group.

Figure 3.

Plasma glucose over time and total AUC in the HW (top) or OW (bottom) group. Nine-hour glucose over time and total AUC in the HW (A, B) or OW (C, D) group. Participants were sedentary for 9 h with three identical meals (SED) or performed 15–30 s of stair climbing "snacks" every hour (SS), with the same meals provided at 0, 180, and 360 min.

Figure 4.

Plasma NEFA over time and total AUC in the HW (top) or OW (bottom) group. Nine-hour plasma NEFA over time and total AUC in the HW (A, B) or OW (C, D) group. Participants were sedentary for 9 h with three identical meals (SED) or performed 15–30 s of stair climbing "snacks" every hour (SS), with the same meals provided at 0, 180, and 360 min. *P < 0.05; t-test was used to compare AUCs between the conditions within each group.

Total Insulin AUC

Study 1 (HW). No significant difference between SS and SED for total insulin AUC was observed (−17.4%, P = 0.24, d = 0.4; Figures 2A, and B).

Study 2 (OW). In participants with OW, a significantly lower total insulin AUC was found in SS versus SED (−16.5%, P = 0.036, d = 0.94; Figures 2C, and 2D).

Total Glucose AUC

Study 1 (HW). No difference was observed for total glucose AUC between SED and SS in HW participants (P = 0.17, d = 0.48; Figures 3A and 3B).

Study 2 (OW). In participants with OW, no significant difference for total glucose AUC between SS and SED was observed (P = 0.31, d = 0.34; Figures 3C and 3D).

Total NEFA AUC

Study 1 (HW). In HW participants, no difference between SS and SED for total NEFA AUC was found (−9%, P = 0.22, d = 0.4; Figures 4A and 3B).

Study 2 (OW). In participants with OW, a significantly lower total NEFA AUC was found in SS versus SED (−21%, P = 0.016, d = 1.2; Figures 4C and 3D).

Total TG AUC

Study 1 (HW). No difference was found for total TG AUC between SS and SED (P = 0.72) in HW participants (Table, Supplemental Digital Content 3, AUC analyses for plasma TG, http://links.lww.com/MSS/C40).

Study 2 (OW). In participants with OW, no significant difference was detected for total TG AUC between SS and SED (P = 0.67; Table, Supplemental Digital Content 3, AUC analyses for plasma TG, http://links.lww.com/MSS/C40).

The primary analyses were supported by the linear mixed-effects model showing a main effect of condition for insulin (P = 0.033) in adults with OW. The meal–condition interaction was not statistically significant (P = 0.31), but there was a main effect of meal (P = 0.002) for 3-h insulin AUC. In adults with OW, pairwise comparisons revealed that 3-h postlunch and postdinner insulin AUCs were lower than 3-h postbreakfast AUC (−22% [P < 0.0001] and −26% [P = 0.0006], respectively). There were no significant main effects of condition (P = 0.65), meal (P = 0.48), or their interaction (P = 0.65) in participants with OW for 3-h postmeal glucose AUC. Main effects of meal were observed for insulin (P < 0.0001) and glucose (P = 0.028) in HW individuals, but there were no main effects of condition (insulin: P = 0.24; glucose: P = 0.18) or meal–condition interactions (insulin: P = 0.72; glucose: P = 0.23). In HW participants, 3-h postlunch and postdinner insulin AUCs were lower than 3-h postbreakfast AUC (−36% [P < 0.0001] and −32% [P < 0.0001], respectively). Also, in HW participants, 3-h postbreakfast glucose AUC was lower compared with postdinner AUC (−5.4%, P = 0.023).

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