Puberty Timing and Adiposity Change Across Childhood and Adolescence

Disentangling Cause and Consequence

Linda M. O'Keeffe; Monika Frysz; Joshua A. Bell; Laura D. Howe; Abigail Fraser

Disclosures

Hum Reprod. 2020;35(12):2784-2792. 

In This Article

Abstract and Introduction

Abstract

Study Question: Is earlier puberty more likely a result of adiposity gain in childhood than a cause of adiposity gain in adulthood?

Summary Answer: Pre-pubertal fat mass is associated with earlier puberty timing but puberty timing is not associated with post-pubertal fat mass change.

What is Known Already: Age at puberty onset has decreased substantially in the last several decades. Whether reducing childhood adiposity prevents earlier puberty and if early puberty prevention itself also has additional independent benefits for prevention of adult adiposity is not well understood.

Study Design, Size, Duration: Prospective birth cohort study of 4176 participants born in 1991/1992 with 18 232 repeated measures of fat mass from age 9 to 18 years.

Participants/Materials, Setting, Methods: We used repeated measures of height from 5 to 20 years to identify puberty timing (age at peak height velocity, aPHV) and repeated measures of directly measured fat mass from age 9 to 18 years, from a contemporary UK birth cohort study to model fat mass trajectories by chronological age and by time before and after puberty onset. We then examined associations of these trajectories with puberty timing separately in females and males.

Main Results and the Role of Chance: In models by chronological age, a 1-year later aPHV was associated with 20.5% (95% confidence interval (CI): 18.6–22.4%) and 23.4% (95% (CI): 21.3–25.5%) lower fat mass in females and males, respectively, at 9 years. These differences were smaller at age 18 years: 7.8% (95% (CI): 5.9–9.6%) and 12.4% (95% (CI): 9.6–15.2%) lower fat mass in females and males per year later aPHV. Trajectories of fat mass by time before and after puberty provided strong evidence for an association of pre-pubertal fat mass with puberty timing, and little evidence of an association of puberty timing with post-pubertal fat mass change. The role of chance is likely to be small in this study given the large sample sizes available.

Limitations, Reasons for Caution: Participants included in our analyses were more socially advantaged than those excluded. The findings of this work may not apply to non-White populations and further work examining associations of puberty timing and fat mass in other ethnicities is required.

Wider Implications of the Findings: Previous research has relied on self-reported measures of puberty timing such as age of voice breaking in males, has lacked data on pre-and post-pubertal adiposity together and relied predominantly on indirect measures of adiposity such as BMI. This has led to conflicting results on the nature and direction of the association between puberty timing and adiposity in females and males. Our work provides important clarity on this, suggesting that prevention of adiposity in childhood is key for prevention of early puberty, adult adiposity and associated cardiovascular risk. In contrast, our findings suggest that prevention of early puberty without prevention of childhood adiposity would have little impact on prevention of adult adiposity.

Study Funding/Competing Interest(S): The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for Avon Longitudinal Study of Parents and Children (ALSPAC). L.M.O.K. is supported by a UK Medical Research Council Population Health Scientist fellowship (MR/M014509/1) and a Health Research Board (HRB) of Ireland Emerging Investigator Award (EIA-FA-2019-007 SCaRLeT). J.A.B. is supported by the Elizabeth Blackwell Institute for Health Research, University of Bristol and the Wellcome Trust Institutional Strategic Support Fund (204813/Z/16/Z). L.D.H. and A.F. are supported by Career Development Awards from the UK Medical Research Council (grants MR/M020894/1 and MR/M009351/1, respectively). All authors work in a unit that receives funds from the UK Medical Research Council (grant MC_UU_00011/3, MC_UU_00011/6). No competing interests to declare.

Trial Registration Number: N/A.

Introduction

Age at puberty onset has decreased substantially among females since the mid-1900s (Euling et al., 2008). Secular trends in males are less well understood due to imprecise markers of pubertal age such as age at voice breaking compared with age at menarche among females (Euling et al., 2008; Kaplowitz, 2008). Earlier puberty directly results in younger fertility and thus carries important social implications (Golub et al., 2008), but it may also have adverse implications for health, with evidence of increased risk of adult obesity, type 2 diabetes, cardiovascular disease and several cancers in both sexes (Prentice and Viner, 2013; Canoy et al., 2014; Charalampopoulos et al., 2014; Day et al., 2015).

Higher BMI before puberty onset is associated with earlier menarche in females, raising the possibility that much of the associations of puberty timing with health in later life reflects tracking of adiposity from childhood (Wang, 2002; Lee et al., 2007; Buyken et al., 2008; Kaplowitz, 2008; Kivimèki et al., 2008; Silventoinen et al., 2008). In males, however, some studies have found that higher childhood BMI is associated with later puberty (Wang, 2002; Lee et al., 2010; 2016), while others have found associations similar to those observed in females (He and Karlberg, 2001; Sandhu et al., 2006; Buyken et al., 2008; Silventoinen et al., 2008; Aksglaede et al., 2009). In a systematic review and meta-analysis of 11 cohort studies, pre-pubertal obesity among females was associated with earlier menarche but there was insufficient and inconsistent evidence in males (Li et al., 2017). A recent Mendelian randomisation (MR) analysis suggested that earlier age at menarche caused higher adult BMI but lacked data on pre-pubertal BMI for adjustment (Gill et al., 2018). In contrast, another recent MR which did have pre-pubertal BMI data suggested that associations of earlier puberty with higher adult BMI were largely confounded by childhood BMI (Bell et al., 2018). Thus, whether pre-pubertal adiposity plays a role in early puberty in females and males and if early puberty also has additional independent associations with post-pubertal adiposity is unclear.

Most prospective studies to date have used self-reported measures of puberty timing such as age of voice breaking in males, have lacked data on pre- and post-pubertal adiposity together and relied predominantly on indirect measures of adiposity such as BMI. In addition, disentangling direction of causality of puberty timing and adiposity may be difficult in available MR studies due to a shared genetic architecture between adiposity and puberty timing (age at menarche) (Day et al., 2015). In this study, we aimed to better understand the association between puberty timing and pre- and post-pubertal adiposity change by examining an objective growth-based measure of pubertal onset (age at peak height velocity (aPHV)) in relation to change in directly measured dual-energy X-ray absorptiometry-derived (DXA-derived) fat mass across childhood and adolescence.

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