Late-onset Myocardial Infarction and Autoimmune Haemolytic Anaemia in a COVID-19 Patient Without Respiratory Symptoms, Concomitant With a Paradoxical Increase in Inflammatory Markers

A Case Report

Maria Chiara Pelle; Bruno Tassone; Marco Ricchio; Maria Mazzitelli; Chiara Davoli; Giada Procopio; Anna Cancelliere; Valentina La Gamba; Elena Lio; Giovanni Matera; Angela Quirino; Giorgio Settimo Barreca; Enrico Maria Trecarichi; Carlo Torti


J Med Case Reports. 2020;14(246) 

In This Article

Abstract and Introduction


Background: In December 2019, a new coronavirus (named severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) spread from China, causing a pandemic in a very short time. The main clinical presentation of SARS-CoV-2 infection (COVID-19, coronavirus disease-2019) is pneumonia, but several cardiovascular complications may also occur (e.g., acute coronary syndromes, pulmonary embolism, stroke, arrhythmias, heart failure and cardiogenic shock). Direct or indirect mechanisms induced by SARS-CoV-2 could be implicated in the pathogenesis of these events.

Case Presentation: We report herein the third case of COVID-19 autoimmune haemolytic anaemia (AIHA) reported so far, which occurredwithout any other possible explanations in a Caucasian patient. The patient also suffered from ST-elevation myocardial injury.

Conclusions: Both complications occurred quite late after COVID-19 diagnosis and were probably precipitated by systemic inflammation, as indicated by a significant delayed increase in inflammatory markers, including interleukin-6 (IL-6).