Disproportionate Incidence of COVID-19 Infection, Hospitalizations, and Deaths Among Persons Identifying as Hispanic or Latino 

Denver, Colorado March-October 2020

Laura Jean Podewils, PhD; Tori L. Burket, MS; Christie Mettenbrink, MPH; Abigail Steiner, MPH; Allison Seidel, MPH; Kenneth Scott, PhD; Lilia Cervantes, MD; Romana Hasnain-Wynia, PhD


Morbidity and Mortality Weekly Report. 2020;69(48):1812-1816. 

In This Article

Abstract and Introduction


Persons identifying as Hispanic or Latino (Hispanic) represent the second largest racial/ethnic group in the United States,[1] yet understanding of the impact of coronavirus disease 2019 (COVID-19) in this population is limited. To evaluate COVID-19 health disparities in the community and inform public health, health system, and community-based interventions, local public health authorities analyzed the sociodemographic characteristics of persons who were diagnosed, hospitalized, and who died with COVID-19 in Denver, Colorado. During the first 7 months of the COVID-19 epidemic in Denver (March 6–October 6, 2020) the majority of adult COVID-19 cases (54.8%), hospitalizations (62.1%), and deaths (51.2%) were among persons identifying as Hispanic, more than double the proportion of Hispanic adults in the Denver community (24.9%).[1] Systemic drivers that influence how Hispanic persons live and work increase their exposure risks: compared with non-Hispanic persons, Hispanic persons with COVID-19 in Denver reported larger household sizes and were more likely to report known exposures to household and close contacts with COVID-19, working in an essential industry, and working while ill. Reducing the disproportionate incidence of COVID-19 morbidity and mortality among Hispanic persons will require implementation of strategies that address upstream social and environmental factors that contribute to an increased risk for both infection and transmission and that facilitate improved access to culturally congruent care.

Staff members from Denver Public Health, a department of Denver Health and Hospital Authority (DHHA), conducted interviews or reviewed medical records for all persons with diagnosed laboratory-confirmed COVID-19 who resided in the city and county of Denver per notification of the Colorado Electronic Disease Reporting System* during March–October 2020. Interviews with persons whose primary language was Spanish were conducted in Spanish by bilingual interviewers or through the DHHA language line, which provides 24/7 access to professional interpreters for over 240 languages. Staff members gathered sociodemographic and epidemiologic information, including potential sources of exposure (e.g., household, close contact, and recent travel), signs and symptoms, symptom onset date, and whether the respondents worked while ill. In early May, the interview form was expanded to include detailed information on industry and occupation according to national guidelines[2] and household size. Because of the large volume of cases and difficulty reaching persons in the hospital, medical chart reviews, rather than telephone interviews, were used to obtain information about persons hospitalized or deceased at the time of COVID-19 diagnosis. Data from case interviews and medical chart reviews were obtained from standardized case report forms, validated for completeness, and entered into a secure REDCap database.[3] The analysis used public health surveillance data and was carried out to understand and inform public health actions to control the spread of COVID-19 in the Denver community; the project was determined to be nonhuman subjects' research and exempt by the Colorado Multiple Institutional Review Board.

The analysis focused on adults aged ≥18 years living in noncongregate settings (excluding persons in long-term care facilities, jails, or in shelters for persons experiencing homelessness) at the time of diagnosis and aimed to identify COVID-19 health disparities in the community to inform public health, health system, and community-based interventions. The proportions of adults with laboratory-confirmed COVID-19, those who were hospitalized for COVID-19, and the proportion of persons with COVID-19 who died were assessed by age, sex, and race/ethnicity. Additional analyses, for each COVID-19 cases and hospitalized patients, focused on comparisons between persons who identified as Hispanic to those who identified as non-Hispanic (all other racial/ethnic groups combined) to assess differences in sociodemographic characteristics, source of COVID-19 exposure, symptoms, occupation, whether they worked while ill, and household size. Occupational industry codes were categorized as essential or nonessential according to a framework developed for Colorado. T-tests and Mann-Whitney tests were used to compare continuous variables, and chi-squared tests were used for categorical variables to determine differences between racial/ethnic groups; an alpha level of 0.05 was used to determine statistical significance. All analyses were conducted in Stata (version 15.0; StataCorp).

The first event of laboratory-confirmed COVID-19 in a Denver resident was reported on March 6, 2020. During the first 7 months of the epidemic in Denver (March 6–October 6), COVID-19 was diagnosed in 10,163 adults living in noncongregate settings, including 1,087 (10.7%) persons who were hospitalized at the time of diagnosis and 165 (1.6%) who died during this period.

The highest proportions of infection occurred among persons aged 25–44 (49.1%) and 45–64 (26.6%) years (Table 1). Race and ethnicity data were available for 9,056 (89.1%) persons with diagnosed COVID-19. A total of 4,959 (54.8%) of persons diagnosed with COVID-19 in Denver occurred among Hispanic persons, approximately double the proportion of adults in Denver identifying as Hispanic (24.9%).[1] In contrast, 32.3% of persons diagnosed with COVID-19 identified as non-Hispanic White (White), and 6.4% identified as non-Hispanic Black or African American (Black), subpopulations that constitute 56.8% and 8.5%, respectively, of Denver adults. The pandemic's initial surge (March 1–June 14, 2020) included more cases and persisted longer among persons of Hispanic ethnicity compared with those of other racial/ethnic groups (Figure). During subsequent surges (June 14–September 5 and September 6–October 3), patterns among Hispanic and White persons were similar, with consistently higher numbers among Hispanic persons.


Adult COVID-19 cases, by race/ethnicity and reported week — Denver, Colorado, March 1–October 3, 2020*
Abbreviation: COVID-19 = coronavirus 2019.
*Only full weeks are depicted in figure during evaluation period.

Hispanic persons accounted for 62.1% of hospitalizations and 51.2% of deaths (Table 1). Whereas Hispanic adults with COVID-19 overall were slightly older than non-Hispanic adults (mean age = 40.8 years versus 39.6 years) (p<0.001), Hispanic adults who were hospitalized with COVID-19 were significantly younger than non-Hispanic adults (mean age = 52.8 years versus 60.2 years) (p<0.001) (Table 2). The distribution of cases was similar among males and females in both Hispanic and non-Hispanic adults. Approximately 90% of both Hispanic and non-Hispanic cases reported symptoms, but Hispanic persons with COVID-19 were significantly more likely than were non-Hispanic persons to report symptoms (p<0.001). Among those who were symptomatic, the median interval between symptom onset and specimen collection was 4 days among Hispanic adults compared with 3 days among non-Hispanic adults (p<0.001). The proportions of Hispanic and non-Hispanic persons who reported experiencing cough, shortness of breath, fatigue, headaches, or diarrhea were similar; however, symptomatic Hispanic patients reported a higher number of total known COVID-19 symptoms (p<0.001) (Table 2). Persons who identified as Hispanic, compared with non-Hispanic, were significantly more likely to report fever or chills (52.7% versus 48.4%; p = 0.03), muscle aches (54.1% versus 48.3%; p<0.001), loss of taste or smell (28.7% versus 22.9%; p<0.001), and a sore throat (34.7% versus 30.7%; p = 0.005).

A higher percentage of symptomatic Hispanic persons with COVID-19 reported working while ill (86.4%) than did non-Hispanic persons with COVID-19 (77.3%; p<0.001). Among the subset of 2,982 (32.9%) persons with detailed employment information available, 68.8% of Hispanic adults reported working in essential industries compared with 60.2% of non-Hispanic adults (p<0.001). Among 3,917 (39.0%) persons with COVID-19 who provided information about household contacts, 38.3% of Hispanic persons reported five or more persons in the household, compared with 13.4% of non-Hispanic persons reporting the same (p<0.001). In addition, reported exposure to a person with known COVID-19 in the household was significantly higher among persons who identified as Hispanic (23.7%) than among those who identified as non-Hispanic (15.2%), as was reporting both exposure within the household and close contact outside the household with a person with known COVID-19 (2.4% versus 1.7%, respectively; p<0.02).