Ischemic Stroke Occurs Less Frequently in Patients With COVID-19

A Multicenter Cross-Sectional Study

Kimon Bekelis, MD; Symeon Missios, MD; Javaad Ahmad, MD; Nicos Labropoulos, PhD; Clemens M. Schirmer, MD, PhD; Daniel R. Calnan, MD, PhD; Jonathan Skinner, PhD; Todd A. MacKenzie, PhD

Disclosures

Stroke. 2020;51(12):3570-3576. 

In This Article

Abstract and Introduction

Abstract

Background and Purpose: The impact of coronavirus disease 2019 (COVID-19) on the occurrence of ischemic stroke has been the subject of increased speculation but has not been confirmed in large observational studies. We investigated the association between COVID-19 and stroke.

Methods: We performed a cross-sectional study involving patients discharged from a healthcare system in New York State, from January to April 2020. A mixed-effects logistic regression analysis and a propensity score–weighted analysis were used to control for confounders and investigate the association of COVID-19 with ischemic stroke. Similar techniques were used to detect the impact of concurrent COVID-19 infection on unfavorable outcomes for patients with stroke.

Results: Among 24 808 discharges, 2513 (10.1%) were diagnosed with COVID-19, and 566 (0.2%) presented with acute ischemic stroke. Patients diagnosed with COVID-19 were at one-quarter the odds of stroke compared with other patients (odds ratio, 0.25 [95% CI, 0.16–0.40]). This association was consistent in all age groups. Our results were robust in sensitivity analyses, including propensity score–weighted regression models. In patients presenting with stroke, concurrent infection with severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) was associated with higher case-fatality (odds ratio, 10.50 [95% CI, 3.54–31.18]) and a trend towards increased occurrence of discharge to rehabilitation (odds ratio, 2.45 [95% CI, 0.81–1.25]).

Conclusions: Using a comprehensive cross-section of patients from a large NY-based healthcare system, we did not identify a positive association between ischemic stroke and COVID-19. However, patients with stroke with COVID-19 had worse outcomes compared with those without, with over a 9-fold increase in mortality. Although no definitive conclusions can be reached from our observational study, our data do not support the concerns for an epidemic of stroke in young adults with COVID-19.

Introduction

There has been recent speculation that coronavirus disease 2019 (COVID-19) is associated with increased risk of fatal ischemic stroke in young adults.[1–3] Multiple theories have been proposed for the pathophysiology of this association, with a procoagulable state in infected patients as the most commonly proposed mechanism.[1] However, several researchers and clinicians are indicating a decreased occurrence of ischemic stroke across the world during the COVID-19 pandemic.[4–6] The drop in perceived occurrence has been so dramatic that many societies and advocacy groups have issued statements[6] urging patients to not delay stroke care in fear of being exposed to severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the virus causing COVID-19.[7] Indeed there has been evidence found for delays in stroke care due to the pandemic.[8] However, no large multi-institutional observational studies support either observation.[9] Despite extensive literature on similar concerns for influenza,[10–12] the evidence for COVID-19 is comprised mainly of small, single-institution case series, without control for confounders and limited generalization. The prior report on stroke and COVID-19 in young adults is limited by selection bias, focusing only on the patients with most severe stroke seen by the neuro-interventional team.[1] This selection reflects the different preferences and backgrounds of the treating physicians, as well as specific patient characteristics. In addition, although concurrent stroke and SARS-CoV-2 infection have been documented in international series before,[13–15] the impact of COVID-19 on stroke outcomes has not been studied. There has been no prior report attempting to account for these limitations through different analytic approaches in a cross-section of patients with COVID-19 of all ages.

We used a comprehensive cross-section of hospital discharges from a large NY-based healthcare system to study the association of COVID-19 with the occurrence of ischemic stroke. The frequency of unfavorable outcomes in patients with ischemic stroke concurrent SARS-CoV-2 infection was also analyzed. Mixed-effects logistic regression and a propensity score matched logistic regression was used to control for confounding.

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