Radiological Case: Breast Cancer Metastasis to the Endometrium

Amy Farkas, MD; Debbie Rigney, MD; Veena Shenoy, MD; Kathryn Nutter, MD


Appl Radiol. 2020;49(6):52-53. 

In This Article


On gross examination, the endometrial cavity was filled by a tan-pink nodular mass measuring 6.1 × 3.8 × 2.2 cm (Figure 2). Microscopic examination demonstrated a poorly differentiated metastatic carcinoma in the uterus consistent with breast primary, with involvement of the uterine endometrium, myometrium, lower uterine segment, cervical mucosa, and stroma (Figure 3). The lesional cells stained strongly positive for ER and HER2 immunohistochemistry (Figure 3). This immunoprofile was consistent with the prior lumpectomy specimen. Mammoglobin, an IHC stain useful for detecting metastatic breast cancer, was also positive (Figure 3).

Figure 2.

Sliced gross pathology specimen of the uterus from total abdominal hysterectomy demonstrates a tan-pink nodular mass that fills the endometrial cavity (arrows).

Figure 3.

Histologic specimens. (A) Histologic section of the tumor demonstrates metastatic carcinoma involving the myometrium (hematoxylin and eosin stain; 4x). (B) Estrogen receptor (ER) immunohistochemistry is positive (20x). (C) Human epidermal growth factor 2 (HER 2) immunohistochemistry is positive (20x). (D) Mammoglobin immunohistochemistry is positive (20x).

Breast cancer most commonly metastasizes to the bone. The lungs, liver, and brain are also common sites of metastatic disease.[1] The most common gynecologic site of metastatic breast cancer is the ovary, followed by the vagina.[2] In contrast, the endometrium is a rare site for primary breast cancer metastasis. Few case reports describe metastatic disease to the uterus, which is most commonly discovered at autopsy.[3] The most common presenting symptom, as in this case, is abnormal vaginal bleeding. Endometrial metastases from breast cancer are most frequently described in cases of invasive lobular carcinoma.[3]

Given the rarity of metastasis to the endometrium, primary endometrial cancer is an additional diagnostic consideration in a breast cancer patient with new onset vaginal bleeding. This is of particular concern in breast cancer patients with hormone receptor positive breast cancer managed with tamoxifen. The agonist effect of tamoxifen on the endometrium increases the risk of primary endometrial cancer two to three times the typical risk of postmenopausal women.[4]

The incidence of endometrial cancer among breast cancer patients treated with tamoxifen is 0.388%, which is presumably more common than metastatic disease to the uterus.[5] Differentiating primary endometrial cancer from breast cancer metastatic to the endometrium has important clinical implications. Primary endometrial cancer may be curable with surgery, whereas metastatic disease to the uterus has only systemic treatment options with an overall poor prognosis.