Obesity Does Not Influence the Outcome of Unicompartmental Knee Arthroplasty for Osteoarthritis

Sarfaroj Khan 


December 01, 2020


Why this matters

  • The use of UKA for single compartment end-stage OA has significantly increased and studies have suggested that this procedure has good functional outcomes and offers several advantages over total knee arthroplasty. However, its use in patients with obesity has been surrounded by controversy.

  • Findings warrant further studies to examine factors associated with obesity and consider stratifying obesity to better delineate any potential differences in outcomes.

Study design

  • 30 studies (mean follow-up duration, 5.42 years) including 80,798 patients met eligibility criteria after a search on MEDLINE, EMBASE, Cochrane, PubMed and Web of Science.

  • Funding: None disclosed.

Key results

  • Subgroup meta-analyses revealed no statistically significant difference following UKA between patients with and without obesity in overall:

    • complication rates (OR, 1.36; 95% CI, 0.54-3.43; P=.52; I2, 97%);

    • infection rates (OR, 1.09; 95% CI, 0.54-2.17; P=.81; I2, 80%); and

    • revision surgeries (OR, 1.60; 95% CI, 0.98-2.62; P=.06; I2, 86%).

  • When further analysing complications, no significant differences were seen in:

    • minor complications (OR, 1.82; 95% CI, 0.69-4.89; P=.23; I2, 91%);

    • major complications (OR, 1.36; 95% CI, 0.32-5.68; P=.68; I2, 97%); and

    • venous thromboembolism rates (OR, 0.77; 95% CI, 0.58-1.01; P=.06; I2, 72%).

  • No significant differences were seen for revision surgeries specifically for:

    • infection (OR, 0.89; 95% CI, 0.49-1.63; P=.71); and

    • aseptic loosening (OR, 1.05; 95% CI, 0.79-1.39; P=.75).


  • Heterogeneity among included studies.


Agarwal N, To K, Zhang B, Khan W. Obesity does not adversely impact the outcome of unicompartmental knee arthroplasty for osteoarthritis: a meta-analysis of 80,798 subjects. Int J Obes (Lond). 2020 Nov 19 [Epub ahead of print]. doi: 10.1038/s41366-020-00718-w. PMID: 33214703 View abstract

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


Comments on Medscape are moderated and should be professional in tone and on topic. You must declare any conflicts of interest related to your comments and responses. Please see our Commenting Guide for further information. We reserve the right to remove posts at our sole discretion.
Post as: