Hypertension is a Stronger Risk Factor for CKD and ESRD in Men Than Women

Sarfaroj Khan 


December 03, 2020


  • This meta-analysis found that the risk of chronic kidney disease (CKD, defined as estimated glomerular filtration rate <60 mL/min/1.73m2/year) and end-stage renal disease (ESRD, defined as the initiation of dialysis, renal transplantation or death due to kidney disease) was 23% lower in women with hypertension than in men with hypertension.

Why this matters

  • This finding may have important implications for improving risk stratification and preventive strategies of CKD and ESRD in the general population.

Study design

  • Meta-analysis of 6 studies including 2,382,712 individuals and 6856 incident CKD events and 833 ESRD events.

  • Funding: None disclosed.

Key results

  • The relative risk (RR) of CKD or ESRD associated with hypertension (systolic BP [SBP] ≥140 mmHg) vs ideal BP (SBP <120 mmHg) was:

    • 1.56 (95% CI, 1.39-1.75) in women; and

    • 2.06 (95% CI, 1.64-2.60; I2, 66.5%) in men.

  • The women to men ratio of RR for incident CKD or ESRD was 0.77 (95% CI, 0.63-0.95; I2, 17.7%).


  • Limited number of studies.


Weldegiorgis M, Woodward M. The impact of hypertension on chronic kidney disease and end-stage renal disease is greater in men than women: a systematic review and meta-analysis. BMC Nephrol. 2020;21(1):506. doi: 10.1186/s12882-020-02151-7. PMID: 33238919 View full text

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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