Takeaway
This meta-analysis found that the risk of chronic kidney disease (CKD, defined as estimated glomerular filtration rate <60 mL/min/1.73m2/year) and end-stage renal disease (ESRD, defined as the initiation of dialysis, renal transplantation or death due to kidney disease) was 23% lower in women with hypertension than in men with hypertension.
Why this matters
This finding may have important implications for improving risk stratification and preventive strategies of CKD and ESRD in the general population.
Study design
Meta-analysis of 6 studies including 2,382,712 individuals and 6856 incident CKD events and 833 ESRD events.
Funding: None disclosed.
Key results
The relative risk (RR) of CKD or ESRD associated with hypertension (systolic BP [SBP] ≥140 mmHg) vs ideal BP (SBP <120 mmHg) was:
1.56 (95% CI, 1.39-1.75) in women; and
2.06 (95% CI, 1.64-2.60; I2, 66.5%) in men.
The women to men ratio of RR for incident CKD or ESRD was 0.77 (95% CI, 0.63-0.95; I2, 17.7%).
Limitations
Limited number of studies.
This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.
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Any views expressed above are the author's own and do not necessarily reflect the views of WebMD or Medscape.
Cite this: Sarfaroj Khan. Hypertension is a Stronger Risk Factor for CKD and ESRD in Men Than Women - Medscape - Dec 03, 2020.
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