No Increased Risk of Fracture in Individuals With Newly Diagnosed Type 2 Diabetes

Sarfaroj Khan 

Disclosures

November 17, 2020

Takeaway

  • This study found no evidence that individuals with newly diagnosed type 2 diabetes (T2D) are at an increased risk of fracture than those without T2D.

  • Women with T2D had a small but statistically significant lower risk of fracture.

Why this matters

  • Findings suggest that individuals should be encouraged to make positive lifestyle changes, including undertaking weight-bearing physical activities that improve bone health following T2D diagnosis.

Study design

  • This population-based cohort study included 174,244 patients with incident T2D and compared their fracture risk over 15 years with 747,290 age-sex-practice matched individuals without T2D using data from The Health Improvement Network (THIN) database, UK.

  • Funding: Division of Health Sciences, University of Otago.

Key results

  • No increased risk of fracture was seen in men with T2D (adjusted hazard ratio [aHR], 0.97; 95% CI, 0.94-1.00) and a small decreased risk was noted in women with T2D (aHR, 0.94; 95% CI, 0.92-0.96).

  • In those aged ≥85 years, those in the T2D cohort were at a significantly reduced risk of incident fracture than those without T2D (men: aHR, 0.85; 95% CI, 0.71-1.00; women: aHR, 0.85; 95% CI, 0.78-0.94).

  • For those in the most deprived areas, those in the T2D cohort were at a lower risk of fracture than those without T2D (men: aHR, 0.90; 95% CI, 0.83-0.98; women: aHR, 0.91; 95% CI, 0.85-0.97).

  • Overweight men with T2D vs those without were at a lower risk of fracture (aHR, 0.91; 95% CI, 0.86-0.96).

  • Similarly, the risk of fracture was lower in obese women (class I or II obese) with T2D vs those without (aHR, 0.91; 95% CI, 0.87-0.95).

  • Annual fracture prevalence rates, by sex, were similar for those with and without T2D.

Limitations

  • Retrospective design.

 

Davie GS, Pal K, Orton E, Tyrrell EG, Petersen I. Incident Type 2 Diabetes and Risk of Fracture: A Comparative Cohort Analysis Using U.K. Primary Care Records. Diabetes Care. 2020 Nov 04 [Epub ahead of print]. doi: 10.2337/dc20-1220. PMID: 33148635 View abstract

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.

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