Is Diabetes an Independent Risk Factor for Venous Thromboembolism?

Sarfaroj Khan 


November 13, 2020


Why this matters

  • T1D should be considered in an at-risk group for VTE; however, the mechanism that underpins the greater risk of VTE in T1D merits further study.

  • Attention should be paid to the type of diabetes when performing and analysing clinical studies on antithrombotic drugs.

Study design

  • A retrospective study of 1,510,351 adults (T1D group: n=7086; T2D group: n=95,566; no diabetes group: n=1,407,699) included in the Royal College of General Practitioners Research and Surveillance Centre database.

  • Primary outcome: occurrence of VTE.

  • Funding: None.

Key results

  • In an unadjusted model, the risk of VTE was increased in patients with T2D (HR, 2.70; 95% CI, 2.57-2.84) but not in those with T1D (HR, 1.00; 95% CI, 0.76-1.33).

  • After adjustment for age and sex, T1D (HR, 1.55; 95% CI, 1.18-2.05) and T2D (HR, 1.31; 95% CI, 1.24-1.38) were associated with an increased risk of VTE.

  • In a fully adjusted model, the risk of VTE was increased in patients with T1D (HR, 1.46; 95% CI, 1.11-1.92) but not in those with T2D (HR, 1.06; 95% CI, 0.98-1.14).

  • Additional adjustment for the presence of cancer, oral contraception or hormone replacement therapy use did not change the association of T1D (HR, 1.45; 95% CI, 1.10-1.92) and T2D (HR, 1.05; 95% CI, 0.97-1.13) with VTE.


  • Retrospective design.


Hinton W, Nemeth B, de Lusignan S, Field B, Feher MD, Munro N, Roberts LN, Arya R, B Whyte M. Effect of type 1 diabetes and type 2 diabetes on the risk of venous thromboembolism. Diabet Med. 2020 Nov 9 [Epub ahead of print]. doi: 10.1111/dme.14452. PMID: 33165941 View abstract

This clinical summary originally appeared on Univadis, part of the Medscape Professional Network.


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