Loss to Follow-up in the Hepatitis C Care Cascade: A Substantial Problem but Opportunity for Micro-elimination

A Substantial Problem But Opportunity for Micro-elimination

Marleen van Dijk; Joost P.H. Drenth


J Viral Hepat. 2020;27(12):1270-1283. 

In This Article

Factors Associated with LTFU

Younger age (~45 and younger),Suppl file 12,46,58,60 treatment in hospital,Suppl file 18 a history of homelessness,Suppl file 19,54 mental illnessSuppl file 15,45 and insurance typeSuppl file 26,60 were some of the most common factors associated with LTFU. Factors associated with retention in care were older age (~60 and older)Suppl file 14,16 and HIV coinfection.Suppl file 14,46 However, one study with HIV coinfected patients showed that detectable HIV viral load was actually associated with LTFU,Suppl file 45 possibly reflecting suboptimal retention in HIV care. Studies on the HCV care cascade in people living with HIV confirm relatively good retention in care, especially after starting treatment.Suppl file 8–11,15,17,45,47–49 The last factors that were often associated with LTFU are linked to injecting drug use. Past,Suppl file 14 recentSuppl file 7,14 or ongoing drug useSuppl file 15,19,45 was mentioned in several studies as being associated with LTFU. Receiving opioid substitution therapy in one centre and DAA treatment in another was also associated with LTFU.Suppl file 7,56