Efficacy of Different Dose of Dexmedetomidine Combined With Remifentanil in Colonoscopy

A Randomized Controlled Trial

Li Jia; Meng Xie; Jing Zhang; Jingyu Guo; Tong Tong; Yuying Xing

Disclosures

BMC Anesthesiol. 2020;20(225) 

In This Article

Results

Characteristics of the Participants

There were no significant differences in general data (age, sex, weight, and examination duration) among the three groups (all P > 0.05) (Table 1). There were no significant differences in SBP, DBP, HR, and RR at T0 among the three groups (all P > 0.05) (Table 2).

Changes in Circulation and Breathing Parameters

Compared with T0, the SBP, HR, and RR at T1–5 in the three groups were all reduced (all P < 0.05), but all were within the clinically normal range (Table 2, Figure 2). SpO2 remained > 98% in all patients during the examination.

Figure 2.

A: Changes of SBP of three groups of patients. B: Figure 2 Changes of DBP of three groups of patients. C: Figure 3 Changes of HR of three groups of patients. D: Figure 4 Changes of RR of three groups of patients

Adverse Reactions

During the examination, 13, six, and three patients in groups I, II, and III, respectively, had slight body movements that did not interfere with the operation or required propofol injection (all P < 0.05). Two patients in group I had body movements that interfered with the operation and needed additional propofol. All patients in each group can be waked up during the examination. For patients who needed to turn over, except for one patient in group III who needed assistance, all patients could turn over on their own. There were 0, one, and six participants of bradycardia in groups I, II, and III, respectively (all P < 0.05). No hypotension occurred in the three groups. Nausea and vomiting occurred in one participant in group I, one in group II, and two in group III (Table 3).

Bispectral Index

Compared with T0, the BIS values of the three groups were decreased at T1 and T2 (all P < 0.05). There were no significant differences in BIS among the three groups (all P > 0.05). The minimum BIS value in group III was lower than in groups I and II (P < 0.05) (Table 4).

Surgeon's Satisfaction

Thirty-five participants in group I were excellent, 13 were good, and two were poor; those numbers were 44, six, and 0, respectively, in group II; and 47, three, and 0, respectively, in group III. The degree of satisfaction with the anesthesia effect was higher in groups II and III that in group I (P < 0.05) (Table 5).

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