Abstract and Introduction
Introduction
Although children and young adults are reportedly at lower risk for severe disease and death from infection with SARS-CoV-2, the virus that causes coronavirus disease 2019 (COVID-19), than are persons in other age groups,[1] younger persons can experience infection and subsequently transmit infection to those at higher risk for severe illness.[2–4] Although at lower risk for severe disease, some young adults experience serious illness, and asymptomatic or mild cases can result in sequelae such as myocardial inflammation.[5] In the United States, approximately 45% of persons aged 18–22 years were enrolled in colleges and universities in 2019.[6] As these institutions reopen, opportunities for infection increase; therefore, mitigation efforts and monitoring reports of COVID-19 cases among young adults are important. During August 2–September 5, weekly incidence of COVID-19 among persons aged 18–22 years rose by 55.1% nationally; across U.S. Census regions,* increases were greatest in the Northeast, where incidence increased 144.0%, and Midwest, where incidence increased 123.4%. During the same period, changes in testing volume for SARS-CoV-2 in this age group ranged from a 6.2% decline in the West to a 170.6% increase in the Northeast. In addition, the proportion of cases in this age group among non-Hispanic White (White) persons increased from 33.8% to 77.3% during May 31–September 5. Mitigation and preventive measures targeted to young adults can likely reduce SARS-CoV-2 transmission among their contacts and communities. As colleges and universities resume operations, taking steps to prevent the spread of COVID-19 among young adults is critical.[7]
CDC receives patient-level COVID-19 data from jurisdictional health departments through a standardized CDC COVID-19 case report form.† Data on probable and confirmed cases from 50 states, the District of Columbia (DC), and four territories (Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands) were analyzed to determine national trends among demographic groups during May 31–September 5, 2020.§ When available, date of symptom onset was used in calculations of weekly trends of case data; if symptom onset date was unavailable, an alternative date was used in the following descending order: specimen collection date, date reported to CDC, or episode date (California only).¶ Trends were analyzed nationally and by U.S. Census region.
Measures of weekly SARS-CoV-2 real-time reverse transcription–polymerase chain reaction (RT-PCR) testing volumes by age were obtained from COVID-19 electronic laboratory reporting data submitted by state health departments (37 states) and from data submitted directly by public health, commercial, and reference laboratories (13 states and DC)** when age was unavailable in state-submitted data. Testing data from U.S. territories were not included. Total number of tests was calculated as the sum of negative and positive test results. Testing volume represents individual tests, not the number of persons tested. Date of specimen collection or test order date was used in calculations of weekly trends in testing volume.††
Data on COVID-19 cases and RT-PCR tests were aggregated by calendar week. Subgroup analyses of case reports and tests were analyzed using two measures: 1) number of reported cases (or tests) per 100,000 population per week (termed incidence for cases), which accounts for differences in underlying population size but is affected by reporting lags and underreporting; and 2) percentage of all cases (or all tests) each week, which does not account for differences in population size but is less affected by reporting lags or underreporting (assuming that reported data do not differ in important ways from lagged data).§§ All analyses were conducted using R software (version 4.0.2; The R Foundation).
During August 2–September 5, 2020, a total 999,579 persons with COVID-19 with case report data were reported to CDC, 15.6% of whom were aged 18–22 years. National weekly COVID-19 incidence among persons aged 18–22 years increased 62.7% (95% confidence interval [CI] = 60.0%–65.3%) during the 4-week period August 2–August 29 from 110 to 180 cases per 100,000 before declining to 171 during August 30–September 5 (Figure 1). During August 2–September 5, weekly incidence increased most in the Northeast (144.0%; 95% CI = 131.5%–157.3%) from 53 to 130 per 100,000, and in the Midwest (123.4%; 95% CI = 116.1%–131.0%), from 111 to 247 (Supplementary Figure 1, https://stacks.cdc.gov/view/cdc/94198). Notably, in the Northeast, weekly incidence has remained below 53 cases per 100,000 in all other age groups since July 4. In the South, weekly incidence among persons aged 18–22 years increased 43.8% (95% CI = 40.0%–47.6%) from 115 to 166 cases per 100,000. Weekly increases were smallest in the West, where incidence declined initially until August 22 and then increased through September 5, but, overall, declined 1.7% during August. During August 2–September 5, the proportion of all cases per week that occurred among persons aged 18–22 years approximately doubled (2.1-fold; 95% CI = 2.1–2.2), from 10.5% to 22.5%.
Figure 1.
Weekly COVID-19 incidence in case surveillance data,* by age group — United States,† May 31–September 5, 2020
Abbreviation: COVID-19 = coronavirus 2019.
*From CDC COVID-19 case report surveillance systems. Case report surveillance systems record 76% of national aggregate case counts reported to CDC, based on an analysis of data reported during March 15–August 15.
†Includes cases in 50 states, District of Columbia, and four territories: Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands.
The number of weekly tests performed among persons aged 18–22 years increased 49.3% (95% CI = 48.7%–49.9%) from 1,877 tests per 100,000 during the week of August 2–August 8 to 2,802 during the week of August 30–September 5 (Figure 2). The largest increase in testing relative to population size was in the Northeast, where weekly tests increased 170.6% (95% CI = 168.3%–172.9%) from 1,975 per 100,000 to 5,345, and in the Midwest, where weekly tests increased 65.2% (95% CI = 63.9%–66.5%) from 2,264 per 100,000 to 3,740 (Supplementary Figure 2, https://stacks.cdc.gov/view/cdc/94197). In contrast, more modest increases were observed in the South (7.0% [95% CI = 6.3%–7.7%], from 2,041 to 2,183 per 100,000); and in the West, testing volume declined 6.2% (95% CI = 5.1%–7.2%), from 1,191 per 100,000 to 1,118. At the end of this period, the proportion of all tests performed nationally among persons aged 18–22 years had increased from 9.4% to 14.4% (1.5-fold [95% CI = 1.53–1.54] higher than at the beginning).
Figure 2.
Total weekly SARS-CoV-2 reverse transcription–polymerase chain reaction (RT-PCR) test volume and percentage of weekly tests,* by age group — United States,† May 31–September 5, 2020
Abbreviation: COVID-19 = coronavirus 2019.
*Percentage of weekly tests was calculated as number of tests within each age group divided by number of tests in all age groups. Specimen collection date or test order date was used for analysis. Tests volume data were obtained from COVID-19 electronic laboratory reporting data submitted by state health departments for 37 states and, when age was not available in state-submitted data, from data submitted directly by public health, commercial, and reference laboratories for 13 states and the District of Columbia. The data might not include results from all testing sites within a jurisdiction (e.g., point-of-care test sites) and therefore reflect the majority of, but not all, SARS-CoV-2 RT-PCR tests in the United States.
†Includes tests conducted in 50 states and District of Columbia.
When examined by race and ethnicity nationally, during August 2–September 5, the weekly incidence among White persons aged 18–22 years increased 149.7% (95% CI = 78.8%–248.7%), from 48 per 100,000 to 120 (Figure 3). During May 31–June 20, the proportion of weekly cases that occurred among White persons aged 18–22 years increased from 33.8%% to 50.8%. Then, during August 2–September 5, the proportion was 1.5-fold that during May 31–June 20 (95% CI = 0.2–12.9), having increased from 52.1% to 77.3%. At the same time, incidence among persons of other racial and ethnic minority groups remained stable or declined. The largest increases in incidence among White persons were in the Midwest (198.2%; from 65 to 195 per 100,000) and the Northeast (168.4%; from 14 to 37 per 100,000) (Supplementary Figure 3, https://stacks.cdc.gov/view/cdc/94196).
Figure 3.
Weekly COVID-19 incidence in case surveillance data* among persons aged 18–22 years, by race/ethnicity†,§ group — United States,¶ May 31–September 5, 2020
Abbreviation: COVID-19 = coronavirus 2019.
*From CDC COVID-19 case report surveillance systems. Case report surveillance systems record 76% of national aggregate case counts reported to CDC, based on an analysis of data reported during March 15–August 15.
†Race/ethnicity data were not reported for 2,476,317 (48.5%) case reports; these cases were excluded from this subgroup analysis.
§Race categories include persons of non-Hispanic ethnicity.
¶Includes cases in 50 states, District of Columbia, and four territories: Guam, the Northern Mariana Islands, Puerto Rico, and the U.S. Virgin Islands.
Morbidity and Mortality Weekly Report. 2020;69(39):1419-1424. © 2020 Centers for Disease Control and Prevention (CDC)
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