Seroprevalence of SARS-CoV-2 Among Frontline Health Care Personnel in a Multistate Hospital Network

13 Academic Medical Centers, April-June 2020

Wesley H. Self, MD; Mark W. Tenforde, MD, PhD; William B. Stubblefield, MD; Leora R. Feldstein, PhD; Jay S. Steingrub, MD; Nathan I. Shapiro, MD; Adit A. Ginde, MD; Matthew E. Prekker, MD; Samuel M. Brown, MD; Ithan D. Peltan, MD; Michelle N. Gong, MD; Michael S. Aboodi, MD; Akram Khan, MD; Matthew C. Exline, MD; D. Clark Files, MD; Kevin W. Gibbs, MD; Christopher J. Lindsell, PhD; Todd. W. Rice, MD; Ian D. Jones, MD; Natasha Halasa, MD; H. Keipp Talbot, MD; Carlos G. Grijalva, MD; Jonathan D. Casey, MD; David N. Hager, MD, PhD; Nida Qadir, MD; Daniel J. Henning, MD; Melissa M. Coughlin, PhD; Jarad Schiffer, MS; Vera Semenova, PhD; Han Li, PhD; Natalie J. Thornburg, PhD; Manish M. Patel, MD


Morbidity and Mortality Weekly Report. 2020;69(35):1221-1226. 

In This Article

Characteristics of Health Care Personnel With and Without SARS-CoV-2 Antibodies

SARS-CoV-2 antibody detection differed among participants according to demographic characteristics. Seropositivity was lower among females (5.3%) than among males (7.2%) (p = 0.03) and among non-Hispanic White participants (4.4%) than among participants of other racial/ethnic groups (9.7%) (p<0.001). Symptoms of an acute viral illness since February 1, 2020, were more prevalent in participants with antibodies detected (71%) than in those without antibodies detected (43%) (p<0.001) (Table). Notably, of 194 participants with antibodies detected, 86 (44%) reported that they did not believe they previously had COVID-19, 56 (29%) reported no symptoms of an acute viral illness since February 1, 2020, and 133 (69%) had not previously had positive test results for acute SARS-CoV-2 infection. A previous positive test was reported by 61 participants, representing 31% of the 194 participants with antibodies detected and 66% of 92 participants with both antibodies detected and previous SARS-CoV-2 testing completed.