Epinephrine in Anaphylaxis: Too Little, Too Late

Jay Adam Lieberman; Julie Wang


Curr Opin Allergy Clin Immunol. 2020;20(5):452-458. 

In This Article


Epinephrine remains underused both by the patient/caregiver and the provider. There are several reasons contributing to this gap in care, some of which can be summarized in Figure 1. Unfortunately, there are sparse data to truly guide us on how epinephrine can best be used, and thus breaking down these barriers to use is difficult. Although continued education is an easy suggestion, education alone will not likely close the gap significantly. Thus, novel studies on how to increase use; increase availability in a cost-effective manner; and newer, effective delivery routes are still needed.

Figure 1.

Multifaceted approach to improving epinephrine use in anaphylaxis.