Epinephrine in Anaphylaxis: Too Little, Too Late

Jay Adam Lieberman; Julie Wang


Curr Opin Allergy Clin Immunol. 2020;20(5):452-458. 

In This Article

Data Suggesting Poor Adherence to Epinephrine Use

Despite the guidance and evidence above, studies show that, in patients presenting with anaphylaxis, epinephrine use either prehospital and/or in the emergency department is suboptimal, and this occurs throughout the world,[21,23,24–31] Table 2).

Rates for epinephrine use will vary by study due several factors (geographic location, population studied, reports of ED and/or pre-ED use, severity of cases selected, etc.); however, it is clear that many patients presenting with anaphylaxis never receive epinephrine, which may have several underlying reasons.