Adrenal Insufficiency in Coronavirus Disease 2019

A Case Report

Maryam Heidarpour; Mehrbod Vakhshoori; Saeed Abbasi; Davood Shafie; Nima Rezaei


J Med Case Reports. 2020;14(134) 

In This Article


Since late December 2019 to April 2020, more than 2.8 million cases of novel coronavirus disease 2019 (COVID-19) have been reported around the world. COVID-19 has a broad spectrum of severity, ranging from asymptomatic to respiratory distress that requires mechanical ventilation.[1–3] However, some patients may develop sepsis, which can happen very quickly and lead to tissue damage, organ failure, and death.[2] In these patients, resistant hypotension might even lead to death in a short time. On the other hand, in the complex setting of critical illness, adrenal insufficiency is easily overlooked as a cause of vasopressor-resistance hypotension.[4] Therefore, it can be assumed that an endocrinological basis could account for some of the extrapulmonary manifestations of COVID-19 infection. Due to the novelty of this pathogen, other presentations of this infection would not be unexpected. In this report, we present the case of a 69-year-old man with COVID-19, who experienced an acute crisis of adrenal insufficiency during hospitalization.