Potentially Inappropriate Medications in Older Adults Living With HIV

B López-Centeno; C Badenes-Olmedo; A Mataix-Sanjuan; JM Bellón; L Pérez-Latorre; JC López; J Benedí; S Khoo; C Marzolini; MJ Calvo-Alcántara; J Berenguer


HIV Medicine. 2020;21(8):541-546. 

In This Article


Ours was a cross-sectional population-based study carried out in the region of Madrid (Spain) between 1 January and 30 June 2017. We analysed the dispensation registry of community and hospital pharmacies from the Madrid Regional Health Service (SERMAS) for this period, looking specifically at PIMs among older PLWH according to the 2019 American Geriatrics Society (AGS) Beers criteria.[4] Older PLWH were defined as those ≥ 65 years old. The SERMAS registry permits access to demographics and all prescription drugs [antiretrovirals (ARVs) and nonantiretroviral medications (co-medications)]. ARVs were categorized according to class. Co-medications were classified according to the Anatomical Therapeutic Chemical (ATC) classification system. Nonantiretroviral polypharmacy (polypharmacy hereafter) was defined as the intake of at least five co-medications.

For the descriptive study, values are expressed as absolute numbers and percentages, and as medians and interquartile ranges (IQRs). Logistic regression analysis was used to investigate factors associated with PIMs. The variables analysed included age, gender, and polypharmacy. IBM SPSS STATISTICS FOR WINDOWS version 21.0 (Armonk, NY, USA) was used for all calculations. All statistical tests were two-sided, and a P-value of < 0.05 was considered statistically significant.