Conclusion
There was a negative correlation between the extent of PD at baseline and the treatment response of RA in patients who received biological therapy. Therefore, the condition of periodontitis might affect ACPA levels and the treatment response of RA. The evaluation of periodontal condition is considered an essential part for the management of RA.
Abbreviations
Δ: Differences in the values before and after treatment; ACPA: Anti-cyclic citrullinated peptide antibody; ACR: American College of Rheumatology; ADA: Adalimumab; CRP: C-reactive protein; csDMARDs: Conventional synthetic disease-modifying antirheumatic drugs; DAS: Disease activity score; ESR: Erythrocyte sedimentation rate; ETN: Etanercept; FDG-PET/CT: Fluorodeoxyglucose-positron emission tomography/computed tomography; IFX: Infliximab; MMP-3: Matrix metalloproteinase 3; MTX: Methotrexate; PD: Periodontitis; P. gingivalis: Porthyomonas gingivalis; PSL: Prednisolone; RA: Rheumatoid arthritis; RF: Rheumatoid factor; ROI: Region of interest; SUV: Standardized uptake value; SUVmax: Maximum standardized uptake value; TCZ: Tocilizumab; TNF: Tumor necrosis factor
Acknowledgements
The authors thank Nobuhiro Tahara in Kurume University School of Medicine for his contributions to the evaluation of the FDG uptake in this study.
Funding
There has been no significant financial support for this work that could have influenced its outcome. The authors acknowledge the financial support provided by a UCB Japan Grant (UCBJ Grant) for the English proofreading and article processing charge of the journal.
Availability of data and materials
All data generated or analyzed during this study are included in this published article and its supplementary information file.
Ethics approval and consent to participate
Ethical approval was obtained from the institutional review board of the Gunma University Hospital. Patients provided written informed consent before taking part in this study.
Arthritis Res Ther. 2020;22(178) © 2020 BioMed Central, Ltd.
Copyright to this article is held by the author(s), licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original citation.
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