Early Detection of Pancreatic Cancer

Sushil Kumar Garg; Suresh T. Chari


Curr Opin Gastroenterol. 2020;36(5):456-461. 

In This Article

Chronic Pancreatitis

Chronic pancreatitis is a risk factor for the development of pancreatic cancer.[29] After excluding patients with a diagnosis of pancreatic cancer within 2 years, the risk of pancreatic cancer is 16-fold in chronic pancreatitis patients compared with the general population.[29] The risk of pancreatic cancer decrease with longer follow-up, but it is still three-fold higher after 9 years of follow-up.[29] Even though chronic pancreatitis is considered a strong risk for pancreatic cancer but less than 5% of patients of chronic pancreatitis develop pancreatic cancer.[30] Possible reasons for increased risk of pancreatic cancer in chronic pancreatitis patients include exposure to tobacco, alcohol, and chronic inflammation leading to carcinogenesis.

Further Enriching the High-risk Population

The goal of the second sieve could is to further enrich the high-risk population (25–50-fold) as from a public health perspective, and even high-risk groups may not justify screening of pancreatic cancer. The second sieve can be done by using a clinical model or identifying a characteristic phenotype in the high-risk group on clinical model, or a highly accurate biomarker.