Moderna Vaccine Protects Against COVID-19 in Monkey Study

Vishwadha Chander

July 30, 2020

(Reuters) - Moderna Inc on Tuesday said its experimental COVID-19 vaccine induced a robust immune response and protected against infection in a study on monkeys.

The vaccine, MRNA-1273, given to non-human primates protected against infection in the lungs and nose, and prevented pulmonary disease in all animals, the company said in a news release. Results of the study in rhesus macaque monkeys were published in the New England Journal of Medicine.

It appeared to be an improvement over results of AstraZeneca's COVID-19 vaccine in a similar study.

While results of the animal study may raise confidence in the vaccine, Moderna has already begun testing it in humans.

On Monday, the company began a late-stage study that intends to test its messenger RNA vaccine against a placebo in 30,000 healthy volunteers. Positive results in that trial could clear the way for regulatory approval and widespread use as early as the end of this year.

Effective vaccines are seen as critical to ending a pandemic that has taking the lives of more than 655,000 people globally.

In the study involving 24 monkeys, Moderna tested doses of 10 micrograms or 100 micrograms of the vaccine against no treatment.

Both doses proved effective at protecting against viral replication in the lungs and lung inflammation, with the larger dose also protecting against viral replication in the nose of the animals.

A rival vaccine being developed by AstraZeneca and Oxford University - among the most advanced in human trials - in a similar animal study also appeared to prevent damage to the lungs and keep the virus from making copies of itself there. But the virus still actively replicated in the nose in that study.

Moderna, which has never brought a vaccine to market, has received nearly $1 billion from the U.S. government for its efforts. The United States is helping bankroll several vaccine candidates under its Operation Warp Speed program.

Moderna shares rose about 2%.


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