Regular Use of Proton Pump Inhibitor and Risk of Rheumatoid Arthritis in Women

A Prospective Cohort Study

Jinqiu Yuan; Changhua Zhang; Jeffrey A. Sparks; Susan Malspeis; Kelvin Kam-Fai Tsoi; Jean H. Kim; Benjamin A. Fisher; Fang Gao; Tim Sumerlin; Yan Liu; Yuxing Liu; Yihang Pan; Yulong He; Joseph J.Y. Sung


Aliment Pharmacol Ther. 2020;52(3):449-458. 

In This Article


Overall, this prospective cohort study indicated that regular use of PPI was associated with increased risk of RA, with a higher risk observed in individuals with a longer duration of use. As PPIs have been linked with other health problems, such as fractures and gastric cancer,[2,3] our study once again suggested the importance of carefully evaluating the need for long-term, continuous use of PPIs. Further research is required to confirm our findings as well as to investigate the underlying mechanisms.