The Effects of Nitrofurazone on Wound Healing in Thoracoabdominal Full-Thickness Skin Defects

Sami Karapolat, MD; Banu Karapolat, MD; Alaaddin Buran, MD; Burcu Kemal Okatan, MD; AtilaTurkyilmaz, MD; Turan Set, MD; CelalTekinbas, MD


Wounds. 2020;32(5):134-141. 

In This Article


The wound healing processes of rats and humans are quite different, especially in terms of the time in which wounds take to heal. Unlike humans, wound healing in rats occurs primarily through contracture. Based on the processes, including timing and the predominant stage of healing, the result obtained here can only be valid for the present study. As such, clinical studies on human subjects should be conducted. Additional limitations of the present study include the small number of rats in the groups, study period being limited to 10 days, and completion of the study with results based on histopathological examination outcomes. With further studies in which more rats are used and nitrofurazone is applied for longer times, more objective results can be obtained and nitrofurazone's appropriate doses, the time it takes for it to show its full effect in wound healing, and its side effects will be better understood. Additionally, microbiology-based experimental studies revealing nitrofurazone's effects at certain times on the number and variety of microorganisms in a wound site and biochemistry-based studies investigating its effect on the mediators, cytokines, and growth factors that play a role in wound healing will provide more comprehensive information on this subject.