Trial Testing Ibuprofen for COVID-19 Launched in London

Dawn O'Shea

June 05, 2020

A trial of lipid ibuprofen to reduce the severity and progression of lung injury in patients with SARS-CoV-2 infections has been launched in South London.

The randomised LIBERATE trial is a collaboration between London’s Guy’s & St Thomas’ NHS Foundation Trust, King’s College London and the pharmaceutical organisation, the SEEK Group. It aims to help refine treatment for COVID-19 with an approach that is distinct from vaccines and anti-viral drugs being researched by other groups.

LIBERATE inclusion criteria are:

  • age ≥18 years;

  • hospitalised;

  • confirmed or suspected SARS-CoV-2 infection;

  • National Early Warning Score (NEWS2) ≥3 in a single parameter or NEWS2 >5 overall;

  • acute hypoxemic respiratory failure: PaO2/FiO2 ratio ≤300 or SpO2/FiO2 ratio <315 (Kigali Modification); and

  • written informed consent.

Primary outcome measures are worsening respiratory failure, defined as severity of hypoxaemia (PaO2/FiO2 ratio or SpO2/FiO2 ratio) and time to or need for mechanical ventilation (time frame for both, 14 days).

Secondary outcome measures are:

  • overall survival;

  • reduction in proportion of patients who require ventilation;

  • reduction in length of critical care stay;

  • reduction in length of hospital stay;

  • modulation of serum pro- and anti-inflammatory cytokines;

  • reduction in duration of ventilation; and

  • increase in ventilator-free days.

Time frame for secondary outcome measures is 28 days.

Professor Richard Beale, Consultant in Intensive Care Medicine, said: "As a new illness, there are limited treatment options for patients with COVID-19. The clinical trial will assess whether this unique formulation of an established drug benefits patients with COVID-19."

This article originally appeared on Univadis, part of the Medscape Professional Network.

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