Dual Therapy With Anti-CGRP Monoclonal Antibodies and Botulinum Toxin for Migraine Prevention

Is There a Rationale?

Lanfranco Pellesi, MD; Thien P. Do, MD; Håkan Ashina, MD; Messoud Ashina, MD, PhD, DMSc; Rami Burstein, PhD


Headache. 2020;60(6):1056-1065. 

In This Article

Search Strategy and Selection Criteria

We searched MEDLINE for articles published from database inception up to December 31st, 2019. We used the search terms "migraine" with the terms "calcitonin gene-related peptide", "CGRP", or "botulinum toxin". Publications were largely selected from the past 10 years but commonly referenced and highly regarded older publications were not excluded. Reference lists of relevant primary articles, reviews, and book chapters were also reviewed to identify studies that may have been missed in the search process.