Long-term Outcome of Patients With Acute Severe Ulcerative Colitis Responding to Intravenous Steroids

Robert Salameh; Julien Kirchgesner; Matthieu Allez; Franck Carbonnel; Antoine Meyer; Jean-Marc Gornet; Laurent Beaugerie; Aurelien Amiot


Aliment Pharmacol Ther. 2020;51(11):1096-1104. 

In This Article


After ASUC responded to IVS, patients presented a slightly higher risk of relapse compared to what was expected from the overall UC population. More importantly, almost two-thirds of patients experienced clinical relapse as a failure of the chosen maintenance therapy, suggesting a need for a more ambitious strategy after ASUC responds to IVS. Early and complete response to IVS and the use of anti-TNF were predictors of better outcome in this setting. Prospective studies are needed to confirm our results.