The Effect of Vitamin D Treatment on Clinical and Biochemical Outcomes of Primary Aldosteronism

Noor Ashikin Ismail; Nor Azmi Kamaruddin; Shamsul Azhar Shah; Norlela Sukor


Clin Endocrinol. 2020;92(6):509-517. 

In This Article


This study demonstrated 70% of PA patients has significant vitamin D insufficiency. Three months of vitamin D treatment resulted in a significant improvement in the 25(OH)vitamin D levels. Vitamin D treatment in this population leads to a significant reduction in the plasma aldosterone concentration, systolic blood pressure, as well as improvement in the eGFR. Vitamin D treatment improves all of these interrelated parameters possibly suggesting an interplay between vitamin D, aldosterone and kidney function.