Atopic Dermatitis and its Relation to Food Allergy

François Graham; Philippe A. Eigenmann


Curr Opin Allergy Clin Immunol. 2020;20(3):305-310. 

In This Article

Early Treatment With Emollients

Treatment of atopic dermatitis with emollients and topical antiinflammatory medication aims at reducing inflammation and repair skin barrier defects.[28] Many studies have evaluated the effect of aggressive emollient treatment in infancy and development of atopic dermatitis and food allergy. A recent study group in the United Kingdom performed a pilot randomized, parallel, single-blind controlled trial of the effect of twice-daily application of ceramide emollient for the first six months of life on the incidence of atopic dermatitis and skin barrier function in 80 high-risk infants up to 12 months of age.[54] There was no significant effect on development of food sensitization and atopic dermatitis, although a trend toward improvement was seen. Another large multicentric study is ongoing in Japan (Prevention of Allergy via Cutaneous Intervention study) to determine whether early aggressive treatment of atopic dermatitis with emollients and topical corticosteroids can prevent development of food allergy.[55]